Comprehensive searches involve searching multiple databases, which results in a significant number of duplicated references (dupes). Remember that dupes are a necessary result of any sensitive search: no dupes = high risk of missing important articles. So, how will you organize all these references, remove duplicates, prepare your citations, and format your final paper? Use a citation manager. 

To learn more about citation management and pick the right software option for you, go here: 
http://guides.library.utoronto.ca/citationmanagement.

Clicking this link will open a new window in your browser. 

If you are a researcher undertaking a systematic or scoping review and are dealing with large numbers of citations, Gerstein librarians recommend any DESKTOP-BASED reference management software, for ex: Endnote Desktop, Mendeley, Papers, or Reference Manager. A web-based citation manager (ex: RefWorks) will be more difficult to work with as it cannot import high numbers of references at the same time.  

If you have already dedicated time and effort to learn a particular program and are happy with it, we say love the one you're with!