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BIO304H5: Physiology of Neurons and Muscle

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The diversity and evolution of ion channels
Dr. Tim JeglaPennsylvania State University, USA
Functional modules in ion channels
Dr. Richard HornJefferson Medical College, USA

Supplemental Readings

Browne, L. E. (2012). Structure of P2X receptors. WIREs Membrane Transport and Signaling,1, 56–69.

Chen, G-Q., Cui, C., Mayer, M. L., & Gouaux, E. (1999). Functional characterization of a potassium-selective prokaryotic glutamate receptor. Nature, 402, 817-821. doi: 10.1038/45568

Miller, C. (2006). ClC chloride channels viewed through a transporter lens. Nature, 440, 484-489. doi:10.1038/nature04713

Scemes, E., Spray, D. C., & Meda, P. (2009). Connexins, pannexins, innexins: novel roles of “hemi-channels.” Pflugers Archiv : European Journal of Physiology457(6), 1207–1226. doi: 10.1007/s00424-008-0591-5

Senatore, A., Guan, W., Boone, A. N., & Spafford, J. D. (2014). T-type channels become highly permeable to Sodium ions using an alternative extracellular turret region (S5-P) outside the selectivity filter. The Journal of Biological Chemistry, 289(17), 11952-11969. doi: 10.1074/jbc.M114.551473